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| Registros recuperados : 19 | |
| 4. |  | ZUMÁRRAGA, M. J.; CATALDI, A.; ARAUJO, F. R.; DIB, C. C.; ROXO, E. Caracterização genética de Mycobacterium bovis em animais de cinco estados brasileiros. O Biológico, São Paulo, SP, v. 74, n. 2, p 95 , jul./dez. 2012. Edição dos resumos da 25ª Reunião Anual do Instituto Biológico, São Paulo, 2012 e 10º Congresso de Iniciação Científica em Ciências Agrárias Biológicas e Ambientais - CICAM, agosto, 2012. Resumo 09.| Biblioteca(s): Embrapa Gado de Corte. |
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| 5. | | SANABRIA, L.; LAGRAVE, L.; NISHIBE, C.; RIBAS, A. C. A.; ZUMÁRRAGA, M. J.; ALMEIDA, N. F.; ARAUJO, F. R. Draft Genome Sequences of Two Mycobacterium bovis Strains Isolated from Beef Cattle in Paraguay. Genome Announcements, v. 5, n. 28, p. 16-17, jul. 2017.| Biblioteca(s): Embrapa Gado de Corte. |
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| 6. | | VIALE, M. N.; ZUMÁRRAGA, M. J.; ARAUJO, F. R.; ZARRAGA, A. M.; CATALDI, A. A.; ROMANO, M. I.; BIGI, F. La genómica de las micobacterias. Revue scientifique et technique (International Office des Epizooties), v. 35, v. 1, p. 215-227, 2016.| Biblioteca(s): Embrapa Gado de Corte. |
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| 7. | | CAZOLA, D de O.; JORGE, K. dos S. G.; ZUMÁRRAGA, M. J.; SOUZA-FILHO, A. F.; ARAUJO, F. R.; OSÓRIO, A. L. A. R. Identificação e genotipagem de Mycobacterium bovis em bovinos positivos no teste intradérmico para tuberculose em Mato Grosso do Sul1. Pesquisa Veterinária Brasileira, v. 35, n. 2, 141-147, fevereiro 2015.| Biblioteca(s): Embrapa Gado de Corte. |
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| 9. | | CAZOLA, D. de O.; JORGE, K. dos S. G.; ZUMÁRRAGA, M J.; SOUZA-FILHO, A. F.; ARAUJO, F. R.; OSÓRIO, A. L. A. R. Identificação e genotipagem de Mycobacterium bovis em bovinos positivos no teste intradérmico para tuberculose em Mato Grosso do Sul. Pesquisa Veterinária Brasileira, Brasília, DF, v. 35, n.2, p. 41-147, fev. 2015.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 10. | | BIGI, M. M.; BLANCO, F. C.; ARAUJO, F. R.; THACKER, T. C.; ZUMÁRRAGA, M. J.; CATALDI, A. A.; SORIA, M. A.; BIGI, F. Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis. Microbiology and Immunology, v. 60, n. 8, p. 552-560, August 2016| Biblioteca(s): Embrapa Gado de Corte. |
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| 11. | | CASTELÃO, A. B. C.; NISHIBE, C.; ZUMÁRRAGA, M. J; CATALDI, A. A.; BIGGI, F; FONSECA JR, A. A.; HODON, M. A; ALMEIDA, N. F.; ARAUJO, F. R. Comparação de genes de virulência de dois isolados de Mycobacterium Bovis sequenciados por plataforma de nova geração. In: JORNADA CIENTÍFICA EMBRAPA GADO DE CORTE, 10., 2014, Campo Grande, MS. [Anais da..]. Campo Grande, MS: Embrapa Gado de Corte, 2014. p.14-15. 2 p. (Embrapa Gado de Corte. Documentos, 208). Comissão organizadora: Grácia Maria Soares Rosinha, Alexandra Rocha de Oliveir, Rodrigo Carvalho Alva.| Biblioteca(s): Embrapa Gado de Corte. |
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| 12. | | CASTELÃO, A. B. C.; NISHIBE, C.; ZUMÁRRAGA, M. J.; CATALDI, A.; BIGI, F.; RAMOS, C. A. do N.; ALMEIDA, V. F.; ARAUJO, F. R. Comparação de genes de virulência de duas cepas de Mycobacterium bovis com perfis patogênicos contrastantes. Campo Grande, MS: Embrapa Gado de Corte, 2015 ( Embrapa Gado de Corte. Boletim de Pesquisa e Desenvolvimento, 33)| Biblioteca(s): Embrapa Gado de Corte. |
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| 13. | | CARNEIRO, P. A. M.; TAKATANI, H.; PASQUATTI, T. N.; SILVA, C. B. D. G.; NORBY, B.; WILKINS, M. J.; ZUMÁRRAGA, M. J.; ARAUJO, F. R.; KANEENE, J. B. Epidemiological Study of Mycobacterium bovis Infection in Buffalo and Cattle in Amazonas, Brazil. Frontiers in Veterinary Science, v. 6, article 434, December, 2019.| Biblioteca(s): Embrapa Gado de Corte. |
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| 14. | | BACANELLI, G.; OLARTE, L. C.; SILVA, M. R.; RODRIGUES, R. A.; CARNEIRO, P. A. M.; KANEENE, J. B.; PASQUATTI, T. N.; TAKATANI, H.; ZUMÁRRAGA, M. J.; ETGES, R. N.; ARAUJO, F. R.; VERBISCK, N. V. Matrix Assisted Laser Desorption Ionization-Time-of-Flight mass spectrometry identification of Mycobacterium bovis in Bovinae. Journal the Veterinary Medical Science, v. 81, n. 10, p.1400?1408, 2019.| Biblioteca(s): Embrapa Gado de Corte; Embrapa Gado de Leite. |
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| 15. | | NISHIBE, C.; CASTELÃO, A. B. C.; COSTA, R. D.; PINTO, B. J.; VARUZZA, L.; CATALDI, A. A.; BERNARDELLI, A.; BIGI, F.; BLANCO, F. C.; ZUMÁRRAGA, M. J.; ALMEIDA, N. F.; ARAUJO, F. R. Draft Genome Sequence of Mycobacterium bovis 04-303, a Highly Virulent Strain from Argentina. Genome Announcements, v. 1, n. 6, p. 1-2, 2013.| Biblioteca(s): Embrapa Gado de Corte. |
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| 16. | | CARNEIRO, P. A. M.; PASQUATTI, T. N.; TAKANI, H.; ZUMÁRRAGA, M. J.; MARFIL, M. J.; BARNARD, C.; FITZGERALD, S. D.; ABRAMOVITCH, R. B.; ARAUJO, F. R.; KANEENE, J. B. Molecular characterization of Mycobacterium bovis infection in cattle and buffalo in Amazon Region, Brazil. Veterinary Medicine and Science, v. 6, p. 133?141, 2020.| Biblioteca(s): Embrapa Gado de Corte. |
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| 17. | | CARNEIRO, P. A. M.; PASQUATTI, T. N.; TAKATANI, H.; ZUMÁRRAGA, M. J.; MARFIL, M. J.; BARNARD, C.; FITZGERALD, S. D.; ABRAMOVITCH, R. B.; ARAUJO, F. R.; KANEEENE, J. B. Molecular characterization of Mycobacterium bovis infection in cattle and buffalo in Amazon Region, Brazil. Veterinary Medicine and Science, v. 6, n. 1, p. 1-9, December, 2019.| Biblioteca(s): Embrapa Gado de Corte. |
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| 18. | | BIGI, M.; VAZQUEZ, C. L.; CASTELÃO, A. B. C.; GARCÍA, E. A.; CATALDI, A. A.; JACKSON, M.; MAcNEIL, M.; SORIA, M.; ZUMÁRRAGA, M. J.; MATIAS, C.; GAGO, G.; BLANCO, F. C.; NISHIBEF, C.; ALMEIDA, N. F.; ARAUJO, F. R.; BIGI, F. Analysing nonsynonymous mutations between two Mycobacterium bovis strains with contrasting pathogenic profiles. Veterinary Microbiology, v. 239, 2019.| Biblioteca(s): Embrapa Gado de Corte. |
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| 19. | | PATANE, J. S. L.; MARTINS JUNIOR, J.; CASTELÃO, A. B.; NISHIBE, C.; MONTERA, L.; BIGI, F.; ZUMÁRRAGA, M. J.; CATALDI, A. A.; FONSECA JUNIOR, A.; ROXO, E.; OSÓRIO, A. L. A. R.; JORGE, K. S.; THACKER, T. C.; ALMEIDA, N. F.; ARAUJO, F. R.; SETUBAL, J. C. Patterns and Processes of Mycobacterium bovis Evolution Revealed by Phylogenomic Analyses. Genome Biology and Evolution, v. 9, n. 3, p. 521-535, March 2017.| Biblioteca(s): Embrapa Gado de Corte. |
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| Registros recuperados : 19 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Gado de Corte. |
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Data corrente: |
30/12/2019 |
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Data da última atualização: |
30/12/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
BIGI, M.; VAZQUEZ, C. L.; CASTELÃO, A. B. C.; GARCÍA, E. A.; CATALDI, A. A.; JACKSON, M.; MAcNEIL, M.; SORIA, M.; ZUMÁRRAGA, M. J.; MATIAS, C.; GAGO, G.; BLANCO, F. C.; NISHIBEF, C.; ALMEIDA, N. F.; ARAUJO, F. R.; BIGI, F. |
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Afiliação: |
Mercedes Bigi, Universidad de Buenos Aires, Facultad de Agronomía, Cátedra de Microbiología Agrícola, INBA-CONICET; Cristina Lourdes Vazquez, Universidad de Buenos Aires, Facultad de Agronomía, Cátedra de Microbiología Agrícola, INBA-CONICET; Ana Beatriz C Castelão, Universidad de Buenos Aires, Facultad de Agronomía, Cátedra de Microbiología Agrícola, INBA-CONICET; Elizabeth Andrea García, Instituto de Biotecnología, IABIMO, CICVyA/INTA; Angel A Cataldi, Instituto de Biotecnología, IABIMO, CICVyA/INTA; Mary Jackson, Colorado State University, Dept. of Microbiology, Immunology and Pathology; Michael McNeil, Colorado State University, Dept. of Microbiology, Immunology and Pathology; Marcelo Soria, Universidad de Buenos Aires, Facultad de Agronomía, Cátedra de Microbiología Agrícola, INBA-CONICET; Martín J Zumárraga, Instituto de Biotecnología, IABIMO, CICVyA/INTA; Matias Cabruja, Laboratory of Physiology and Genetics of Actinomycetes, Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario; Gabriela Gago, Laboratory of Physiology and Genetics of Actinomycetes, Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario; Federico C Blanco, Instituto de Biotecnología, IABIMO, CICVyA/INTA; Christiane Nishibef, Universidade Federal de Mato Grosso do Sul - UFMS/Faculdade de Computação; Nalvo F Almeida, Universidade Federal de Mato Grosso do Sul - UFMS/Faculdade de Computação; FLABIO RIBEIRO DE ARAUJO, CNPGC; Fabiana Bigi, Instituto de Biotecnología, IABIMO, CICVyA/INTA. |
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Título: |
Analysing nonsynonymous mutations between two Mycobacterium bovis strains with contrasting pathogenic profiles. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Veterinary Microbiology, v. 239, 2019. |
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Idioma: |
Inglês |
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Conteúdo: |
Mycobacterium bovis (M. bovis) is the causative agent of bovine tuberculosis, a chronic infectious disease that can affect cattle, other domesticated species, wild animals and humans. This disease produces important economic losses worldwide. Two M. bovis strains (04-303 and 534) have been isolated in Argentina. Whereas the 04-303 strain was isolated from a wild boar, the 534 strain was obtained from cattle. In a previous study, six weeks after infection, the 04-303 strain induced 100% mortality in mice. By contrast, mice infected with the 534 strain survived, with limited tissue damage, after four months. In this study we compared all predictive proteins encoded in both M. bovis genomes. The comparative analysis revealed 141 polymorphic proteins between both strains. From these proteins, nine virulence proteins showed polymorphisms in 04-303, whereas five did it in the 534 strain. Remarkably, both strains contained a high level of polymorphism in proteins related to phthiocerol dimycocerosate (PDIM) synthesis or transport. Further experimental evidence indicated that only mutations in the 534 strain have an impact on PDIM synthesis. The observed reduction in PDIM content in the 534 strain, together with its low capacity to induce phagosome arrest, may be associated with the reported deficiency of this strain to replicate and survive inside bovine macrophages. The findings of this study could contribute to a better understanding of pathogenicity and virulence aspects of M. bovis, which is essential for further studies aiming at developing new vaccines and diagnostic techniques for bovines. MenosMycobacterium bovis (M. bovis) is the causative agent of bovine tuberculosis, a chronic infectious disease that can affect cattle, other domesticated species, wild animals and humans. This disease produces important economic losses worldwide. Two M. bovis strains (04-303 and 534) have been isolated in Argentina. Whereas the 04-303 strain was isolated from a wild boar, the 534 strain was obtained from cattle. In a previous study, six weeks after infection, the 04-303 strain induced 100% mortality in mice. By contrast, mice infected with the 534 strain survived, with limited tissue damage, after four months. In this study we compared all predictive proteins encoded in both M. bovis genomes. The comparative analysis revealed 141 polymorphic proteins between both strains. From these proteins, nine virulence proteins showed polymorphisms in 04-303, whereas five did it in the 534 strain. Remarkably, both strains contained a high level of polymorphism in proteins related to phthiocerol dimycocerosate (PDIM) synthesis or transport. Further experimental evidence indicated that only mutations in the 534 strain have an impact on PDIM synthesis. The observed reduction in PDIM content in the 534 strain, together with its low capacity to induce phagosome arrest, may be associated with the reported deficiency of this strain to replicate and survive inside bovine macrophages. The findings of this study could contribute to a better understanding of pathogenicity and virulence aspects of M. b... Mostrar Tudo |
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Palavras-Chave: |
Mutations. |
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Thesagro: |
Gene. |
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Thesaurus NAL: |
Genome; Mycobacterium bovis BCG; Virulence. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/207981/1/Analysing-nonsynonymous-mutations.pdf
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Marc: |
LEADER 02585naa a2200361 a 4500
001 2117921
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008 2019 bl uuuu u00u1 u #d
100 1 $aBIGI, M.
245 $aAnalysing nonsynonymous mutations between two Mycobacterium bovis strains with contrasting pathogenic profiles.$h[electronic resource]
260 $c2019
520 $aMycobacterium bovis (M. bovis) is the causative agent of bovine tuberculosis, a chronic infectious disease that can affect cattle, other domesticated species, wild animals and humans. This disease produces important economic losses worldwide. Two M. bovis strains (04-303 and 534) have been isolated in Argentina. Whereas the 04-303 strain was isolated from a wild boar, the 534 strain was obtained from cattle. In a previous study, six weeks after infection, the 04-303 strain induced 100% mortality in mice. By contrast, mice infected with the 534 strain survived, with limited tissue damage, after four months. In this study we compared all predictive proteins encoded in both M. bovis genomes. The comparative analysis revealed 141 polymorphic proteins between both strains. From these proteins, nine virulence proteins showed polymorphisms in 04-303, whereas five did it in the 534 strain. Remarkably, both strains contained a high level of polymorphism in proteins related to phthiocerol dimycocerosate (PDIM) synthesis or transport. Further experimental evidence indicated that only mutations in the 534 strain have an impact on PDIM synthesis. The observed reduction in PDIM content in the 534 strain, together with its low capacity to induce phagosome arrest, may be associated with the reported deficiency of this strain to replicate and survive inside bovine macrophages. The findings of this study could contribute to a better understanding of pathogenicity and virulence aspects of M. bovis, which is essential for further studies aiming at developing new vaccines and diagnostic techniques for bovines.
650 $aGenome
650 $aMycobacterium bovis BCG
650 $aVirulence
650 $aGene
653 $aMutations
700 1 $aVAZQUEZ, C. L.
700 1 $aCASTELÃO, A. B. C.
700 1 $aGARCÍA, E. A.
700 1 $aCATALDI, A. A.
700 1 $aJACKSON, M.
700 1 $aMAcNEIL, M.
700 1 $aSORIA, M.
700 1 $aZUMÁRRAGA, M. J.
700 1 $aMATIAS, C.
700 1 $aGAGO, G.
700 1 $aBLANCO, F. C.
700 1 $aNISHIBEF, C.
700 1 $aALMEIDA, N. F.
700 1 $aARAUJO, F. R.
700 1 $aBIGI, F.
773 $tVeterinary Microbiology$gv. 239, 2019.
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